Cell Death Differ. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. TLR4 enhances TGF-beta signaling and hepatic fibrosis. 1995; (33):212-4. People in Profiles who have published with this person. Thomas E. Starzl: Transplantation pioneer. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Acceptance Post-Bac. 2014 Oct 28; 83(18):1653-60. 2017 Feb 01; 312(2):C131-C143. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. Expression of small heat shock protein alphaB-crystallin is induced after hepatic stellate cell activation. J Clin Invest. 2003 Apr 15; 170(8):4053-60. PLoS One. J Clin Immunol. University of California San Diego named John M. Carethers as the vice chancellor for Health Sciences (VCHS), effective January 1, 2023. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS. 2003 Oct; 125(4):1009. 2013 Dec; 11(12):1636-45.e1-3. PLoS One. Insulin-like growth factor-I and epidermal growth factor interact to regulate growth and gene expression in IEC-6 intestinal epithelial cells. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. Cell Metab. 2004 Aug 15; 78(3):324-32. Am J Physiol. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Therapeutic strategies for hepatic fibrosis. Gastroenterology. Cell Metab. Am J Physiol Cell Physiol. 1985 Apr; 5(4):684-91. J Hepatol. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Am J Physiol Heart Circ Physiol. Yilmaz R, Weishaupt K, Valkadinov I, Knehr A. Wastewater sequencing uncovers early, cryptic SARS-CoV-2 variant transmission. Molecular epidemiology and cancer prevention. Diehl AM, Yin M, Fleckenstein J, Yang SQ, Lin HZ. The Clinical Research Forum and Association of American Physicians disagree with criticism of the NIH Roadmap. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. 1991 12; 54(6 Suppl):1141S-1143S. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Am J Physiol. J Hepatol. 2006 Jul; 37(7):1691-6. The mitochondrial permeability transition is required for tumor necrosis factor alpha-mediated apoptosis and cytochrome c release. 2018 09; 68(3):918-932. Paik YH, Kim J, Aoyama T, De Minicis S, Bataller R. Transcriptional repression of the transforming growth factor (TGF-) Pseudoreceptor BMP and activin membrane-bound inhibitor (BAMBI) by Nuclear Factor ?B (NF-?B) p50 enhances TGF- signaling in hepatic stellate cells. 2000 Jan 15; 28(2):641-7. Nat Immunol. David has 2 jobs listed on their profile. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Collagen Formation Assessed by N-Terminal Propeptide of Type 3 Procollagen Is a Heritable Trait and Is Associated With Liver Fibrosis Assessed by Magnetic Resonance Elastography. J Biol Chem. Clin Liver Dis. 2013 Jun; 45(6):450-9. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. 2005 Mar; 39(3):181-8. J Biol Chem. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. 2011 Apr; 300(4):G516-25. Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. J Biol Chem. Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L. Targeting the Wnt signaling pathway through R-spondin 3 identifies an anti-fibrosis treatment strategy for multiple organs. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Curr Opin Gastroenterol. TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis. Am J Physiol. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. Am J Epidemiol. Gastroenterology. J Bioenerg Biomembr. Chojkier M, Flaherty M, Peterkofsky B, Majmudar GH, Spanheimer RG. Yale J Biol Med. Korean J Hepatol. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. 2008 Aug; 42(5):349-61. 2004 Apr; 18(6):720-2. Am J Physiol Gastrointest Liver Physiol. J Gastroenterol Hepatol. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Surgery. Mechanisms of liver fibrosis and its role in liver cancer. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. Liver Transpl. In this role, he leads the School of J Lab Clin Med. 2002 Sep; 123(3):877-8. Next-generation academic medicine. 2020 01; 245(2):96-108. Neurobiol Aging. 2018 01; 53(1):6-17. Hepatology. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Hum Mol Genet. Mol Biol Med. 2015 Nov-Dec; 49 Suppl 1:S69-73. 2021 07 20; 118(29). Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). J Hepatol. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. Clin Gastroenterol Hepatol. Liver Transpl Surg. 1994 Sep; 17(3):410-2. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Proc Natl Acad Sci U S A. Expression of collagen genes in the liver. Recent advances in liver stem cell therapy. Am J Physiol Gastrointest Liver Physiol. 1993 Feb; 17(2):287-92. J Clin Gastroenterol. 1998 Nov; 18(11):6353-64. Cell Metab. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. J Biol Chem. New functions for the aryl hydrocarbon receptor. Hepatology. Mol Cell Biol. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. Am J Physiol Gastrointest Liver Physiol. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. 2000 Sep 29; 275(39):30597-604. 1989 Aug 15; 49(16):4446-51. 2022 10; 610(7931):366-372. Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. 2017 09 15; 331:135-141. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Hepatology. Bradykinin attenuates hepatocellular damage and fibrosis in rats with chronic liver injury. Circulation. Gastroenterology. USC undermined our ability to do research. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. 2019 07 23; 116(30):15184-15193. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. J Biol Chem. Nucleic Acids Res. Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M. Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis. Mixed-methods quantitative-qualitative study of 29 nonagenarians and centenarians in rural Southern Italy: focus on positive psychological traits. What is the potential role of antifibrotic agents for the treatment of liver disease? To see the data as text. Gut. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H. Analysis of signaling protein kinases in human colon or colorectal carcinomas. 2011 Jul; 179(1):189-98. Methods Mol Biol. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. 1979 Sep-Oct; 52(5):449-54. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. 1998 10; 275(4):C1058-66. Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. 1999 Apr 15; 162(8):4447-54. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. 2009 Jan; 130(1):16-26. J Clin Exp Hepatol. 2020 01 07; 31(1):189-206.e8. J Hepatol. 2004 Feb; 24(4):1758-68. 2000 Apr 21; 275(16):12207-13. 2016; 7:47. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? 2007 Feb; 27(1):28-43. 1991 Jun; 87(6):2230-5. The recombination and integration of DNAs introduced into mouse L cells. 2005; 23(3-4):255-63. Haploinsufficiency of TANK-binding kinase 1 prepones age-associated neuroinflammatory changes without causing motor neuron degeneration in aged mice. 1995 Oct; 269(4 Pt 1):G591-9. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Hepatic stellate cells secrete angiopoietin 1 that induces angiogenesis in liver fibrosis. 2000 Feb; 31(2):391-8. J Clin Invest. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. The role of Smad3 in mediating mouse hepatic stellate cell activation. J Immunol. La Jolla groups issue letter on city parks master plan. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. 2001; 160:459-79. 2019 03 29; 10(1):1406. 2007 May; 132(5):1937-46. 2020; 2(2):fcaa133. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Am J Physiol Gastrointest Liver Physiol. Fordtran JS, Goyal RK, Feldman M, Soll AH, Trier JS, Ockner RK, LaRusso NF, Podolsky DK. 2001 May; 25(5 Suppl ISBRA):251S-253S. Aliment Pharmacol Ther. 1998 Jul 01; 102(1):107-14. In Vitro Cell Dev Biol. Alcohol Clin Exp Res. Am J Physiol. J Clin Invest. 2009 Apr; 136(4):1423-34. J Mol Med (Berl). Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. 2004 Nov; 40(5):1106-15. 2003 Nov; 112(9):1383-94. 2003 Apr; 38(4):468-75. Activation of activating protein 1 during hepatic acute phase response. J Biol Chem. Gastroenterology. Am J Pathol. Hepatology. 2006 Jul; 86(7):676-86. Bataller R, Gbele E, Parsons CJ, Morris T, Yang L, Schoonhoven R. Anandamide induces necrosis in primary hepatic stellate cells. Ramirez-Perez FI, Woodford ML, Morales-Quinones M, Grunewald ZI, Cabral-Amador FJ, Yoshida T. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Alcohol Clin Exp Res. J Immunol. 1999 Oct; 18(10):751-61. 2021; 12(1):293-320. Am J Pathol. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. 2023 Jan 17; 1-6. PLoS One. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. NOX in liver fibrosis. Dig Dis. Diagnosis and management of patients with a1-antitrypsin (A1AT) deficiency. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. 2006 Aug; 116(8):2058-9. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. 1990; 24:352-8. 1989 May; 8(4):279-85. 2002 Sep; 132(3):441-9. Clin Gastroenterol Hepatol. 2006 Jul 27; 82(2):241-50. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. Proc Natl Acad Sci U S A. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Neurogastroenterol Motil. Nucleic Acids Res. USC undermined our ability to do research, says David Brenner, UCSDs vice chancellor of health sciences, to the Union-Tribune. 2004 Oct; 127(4):1260-2. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. 2007 Jun; 132(7):2601-4. Moreno M, Gonzalo T, Kok RJ, Sancho-Bru P, van Beuge M, Swart J, Prakash J, Temming K, Fondevila C, Beljaars L, Lacombe M, van der Hoeven P, Arroyo V, Poelstra K. Hepatic progenitors for liver disease: current position. Allergy. 2022 07 05; 34(7):978-990.e4. 2014 Aug 12; 111(32):E3297-305. 2008 Dec; 48(6):2016-26. 2007 Nov; 2(4):243-4. A simplified method for the preparation of transcriptionally active liver nuclear extracts. J Burn Care Rehabil. Front Mol Biosci. 2010 Sep; 139(3):987-98. Gastroenterology. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. The fecal microbiome of ALS patients. Moderate alcohol drinking: effects on the heart and liver. Prog. Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study. Hepatology. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. Hepatology. Biology (Basel). Derived automatically from this person's publications. 2005 Dec; 42(6):1320-8. Hepatology. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. Best Pract Res Clin Gastroenterol. Mechanisms of hepatic toxicity. 2007 Dec; 47(6):834-43. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. 2007 Dec; 133(6):2019-28. Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. J Theor Biol. Cell. This graph shows the total number of publications by year. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. 2020 May 05; 56(5). Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. 2000 Jan; 118(1):90-100. 2020 Apr; 4(4):606-626. 2019 Apr 07; 20(7). 2014 Mar 07; 289(10):7082-7091. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Proc Am Thorac Soc. 2009 Nov; 58(11):1517-27. 2020 Nov 03; 32(5):901. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. Mitogens and hepatocyte growth control in vivo and in vitro. 2013 Mar; 62(3):335-6. 1994 Sep; 14(9):5950-60. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. 2005 Jun 10; 280(23):21763-72. 1989 Jun 05; 264(16):9583-91. J Hepatol. Hepatology. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 2007 Dec; 52(12):3404-15. Xu Y, Bialik S, Jones BE, Iimuro Y, Kitsis RN, Srinivasan A. Porphyrias. Compr Ther. Aliment Pharmacol Ther. 1996 Sep; 24(3):670-6. This graph shows the total number of publications by year. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. 2009 Mar 03; 106(9):3300-5. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Am J Physiol. J Gastroenterol Hepatol. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. 2012 Sep; 143(3):765-776.e3. Protective effect of human serum amyloid P on CCl4-induced acute liver injury in mice. Biochem Soc Symp. Curr Opin Gastroenterol. J Clin Invest. Hepatology. Gastroenterology. 1992 Feb 28; 183(1):184-92. Characterization of the interaction between alphaCP(2) and the 3'-untranslated region of collagen alpha1(I) mRNA. 2002 Aug 15; 100(4):1470-7. A logical approach to the patient with jaundice. Interactions between the intestinal microbiome and liver diseases. 2003 Jan 01; 8:d69-77. J Clin Invest. DNA. 1988 Jan-Feb; 8(1):176-82. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. J Clin Invest. 1992 May; 4(5):43-58. Arch Clin Biomed Res. Joint statement on missions and submissions of papers to AGA journals. Iimuro Y, Nishiura T, Hellerbrand C, Behrns KE, Schoonhoven R, Grisham JW. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. J Clin Gastroenterol. Am J Physiol Cell Physiol. Gastroenterology. Black D, Bird MA, Samson CM, Lyman S, Lange PA, Schrum LW, Qian T, Lemasters JJ. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Gastroenterology. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. J Clin Invest. 2019 01; 49(2):183-193. Exp Biol Med (Maywood). Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Note that an individual publication can be assigned to more than one field. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. 2012 Nov; 122(11):4280-2. Liver Int. 2015 Jul; 22(7):512-8. Liedtke C, Plmpe J, Kubicka S, Bradham CA, Manns MP. 1994 Jun 21; 91(13):6030-4. Gastroenterology. What goes up must come down: the emerging role of microRNA in fibrosis. Mol Cell Biol. Hepatology. Aging Ment Health. 2012 Jun; 56(6):1283-92. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. 2006 Oct; 21 Suppl 3:S84-7. 2000 Feb; 88(2):142-9. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. Gastroenterology. Semin Liver Dis. Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. 1999; 8(3):151-63. 1999 Oct 22; 274(43):30919-26. 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