sandifer's syndrome vs infantile spasms

[19][20][21], Patients are grouped into symptomatic versus cryptogenic versus idiopathic IS, butclinicians must be able first to identify the clinical features that prompt further investigation of IS as a diagnosis. This pattern comprises very high voltage, random, slow waves and spikes in all cortical areas.[13]Spikes may occur in a generalized manner but are never rhythmic or organized as would beseen in childhood absence epilepsy. In the infant reflux world we consider it to be reflux taken to the next level, a neurological one. Gastric Symptoms in Infants and. The differential diagnosis for infantile spasm is broad including mild diagnoses such as colic, gastroesophageal reflux, spasticity, benign neonatal sleep myoclonus, or excessive startles or Moro reflexes up to more severe diagnosis. Patients with idiopathic IS have normal development before the onset of symmetric spasms, a normal examination, normal neuroimaging, and hypsarrhythmic EEG pattern without focal epileptiform abnormalities.[2]. The Neurologist suggest Sandifer's Syndrome and has referred us back to Ped. The classical symptoms of the syndrome are spasmodic torticollis and dystonia [23]. View. 14. However, its almost always related to a problem with the lower esophagus, which leads into the stomach, or a hiatal hernia. This reinforces why it is important for clinicians to be aware of the signs of IS andthe diagnostic strategies and best practices; time is the prognosis for IS. Additional symptoms of Sandifer syndrome and GERD include: Doctors arent sure about the exact cause of Sandifer syndrome. An epileptic spasm is a specific type of seizure seen in an epilepsy syndrome of infancy and childhood often called West Syndrome. Taghdiri MM, Nemati H. Infantile spasm: a review article. One may also note changes in respiratory patterns. StatPearls Publishing, Treasure Island (FL). may email you for journal alerts and information, but is committed This syndrome was first mentioned more than 50 years ago with minimal documentation in the medical literature. It is a disorder that affects mostly those in the first year of life and is described as spasms with characteristic EEG changes known as hypsarrhythmia and a strong association with developmental delay or regression. In cases that arerefractory to initial treatment with ACTH or vigabatrin, clinicians may consider initiation of a ketogenic diet. Symptoms are most common after your baby eats when the contents of their stomach dont settle. [23]Associated with the spasms include motor arrest, lasting up to 90 seconds, as well as rhythmic nystagmoid eye movements or eye deviation. Shields WD, Shewmon DA, Chugani HT, Peacock WJ. Studies show that nearly 7% of infants in the United States have gastroesophageal reflux disease (GERD) and less than 1% of those infants experience muscle spasms. Guggenheim MA, Frost JD, Hrachovy RA. Sandifer syndrome is uncommon and clinically presents with a sudden onset of transient, spasmodic torsional dystonia with arching of the back and opisthotonic posturing (positioning of the head and heels backward and the spine arching forward, with intermittent torticollis) in patients with GERD or hiatal hernia.1,2 The movements associated with this disorder are disturbing to parents and can perplex clinicians because the presentation can mimic seizures.3 However, prompt recognition and treatment will quickly resolve the disorder. Once ACTH therapy is begun the time to effectiveness with a cessation of spasms was 7 to 12 days. The spectrum of nonepileptic events in children. Both of those things are outgrown without intervention. Some studiesdetermine a slightly higher rate of males compared to females being affected with a ratio of 60:40. Eighty-seven percent of surgical patients who had a hiatal hernia responded to surgery and the symptoms of Sandifer syndrome resolved. Hodgeman RM, Kapur K, Paris A, Marti C, Can A, Kimia A, Loddenkemper T, Bergin A, Poduri A, Libenson M, Lamb N, Jafarpour S, Harini C. Effectiveness of once-daily high-dose ACTH for infantile spasms. Other researchers suggest that stimulating the diaphragm could cause the reflexive neck muscle contractions (Figure 3).8,16 This also does not adequately explain why these postures do not occur during sleep. Babies with the condition will often experience clusters of . There is a peculiar epidemiological profile of IESS in South Asia. Ohtahara S, Ohtsuka Y, Yamatogi Y, Oka E, Yoshinaga H, Sato M. Prenatal etiologies of West syndrome. Irritability during feeding, wet burps or hiccups, abnormal arching, Two batches of Enfamil ProSobee infant formula have been voluntarily recalled due to possible contamination with a bacteria called Cronobacter, Researchers say a school-based physical activity program in Slovenia has helped ease childhood obesity, but not all experts agree with the findings, Experts say parents sometimes give children fever-reducing medication when it's not necessary, noting that higher temperatures are a way the body. AAPA Members can view Full text articles for FREE. Kinsbourne M. Hiatus hernia with contortions of the neck. Atrial Fibrillation and Stroke. Early diagnosis is critical, as treatment is simple and leads to prompt resolution of the movement disorder. Those were the alternate 2 diagoses that my pediatrician gave me. GERD frequently is diagnosed by its signs, symptoms, and physical examination.1 Initiating empiric treatment can be a simple and cost-effective means of confirming the condition.13 Upper GI and scintigraphy studies may help evaluate for anatomical abnormalities such as hiatal hernia but are not recommended as first-line studies for GERD.9 A full discussion of diagnosing GERD is beyond the scope of this article. Wolters Kluwer Health Please try again soon. [2], Sandifer syndrome was first described in 1964 by Austrian neurologist Marcel Kinsbourne in The Lancet. Case studies verified that the posturing does not return once the GERD or hiatal hernia is successfully treated.8,15 If GERD is suspected or diagnosed, research recommends starting with the standard treatment approach for GERD in children, as outlined in the comprehensive guideline from the North American and European Societies of Pediatric Gastroenterology, Hepatology, and Nutrition.17, Lifestyle changes are the first step in treating GERD and Sandifer syndrome. Current research using animal modelsis being performed to contribute to the understanding of the pathophysiology of IS. Efficacy of conservative therapy as taught in the primary care setting for symptoms suggesting infant gastroesophageal reflux. Each premiseissupported by autopsy studies as well as neuroimaging, EEG findings, and neurotransmitter abnormalities. CryptogenicIS is associated with a better prognosis as compared to symptomatic IS. 7. Sandifer Syndrome. Symptoms of infantile spasms What do infantile spasms look like? Clinicians should have a high index of suspicion for Sandifer syndrome when a child presents with intermittent torticollis or atypical posturing in the absence of injury or disease. [28]At this time it is recommended that the ketogenic diet bean adjunct to ACTH or vigabatrin or cases refractory to treatment. Clinicians must be able to identify and begin early diagnostic testing for IS because time is important to prognosis. Look up infant tremors and sandifer's syndrome. Cafarotti A, Bascietto C, Salvatore R, et al. You may search for similar articles that contain these same keywords or you may The last stage is characterized by a progressive decrease in spasm frequency and severity. If none of these changes work, your childs doctor might suggest medication, including: Each of these medicines has potential side effects and may not always reduce symptoms. [13]ACTH is thought to work by suppression of corticotropin-releasing hormone that in animal models was found to be an endogenous neuropeptide that provoked convulsions. The International League Against Epilepsy has proposed the term "infantile epileptic spasms syndrome (IESS . Your message has been successfully sent to your colleague. Sandifer syndrome was first recorded in the early 1960s, and the exact number of cases is unknown. Vigevano F, Fusco L, Cusmai R, Claps D, Ricci S, Milani L. The idiopathic form of West syndrome. Vandenplas Y, Salvatore S, Hauser B. [28]While a patient is receiving treatment clinicians should monitor blood pressure, serum glucose, potassium and sodium,screen forcushingoid featuresand be cognizant of any signs of infection.[1]. Acid reflux: This is when stomach acid journey to your esophagus and throat and causes pain . Associated symptoms, such as epigastric discomfort, vomiting (which may involve blood) and abnormal eye movements have been reported. Cerebral dysgenesis, lissencephaly,holoprosencephaly, andhemimegalencephalyaccount for theadditionalCNS malformations that can be associated withIS. Prokinetic agents such as metoclopramide are not recommended because the benefits are outweighed by risks such as irritability, lethargy, extrapyramidal reactions, and permanent tardive dyskinesia.17 A study by Kabaku and Kurt showed that the addition of medication to the treatment regimen led to a dramatic decrease in posturing events.6 Agents such as histamine2-receptor antagonists and PPIs reduce the amount of acid secretion in the stomach. Hi I posted a while ago regardin seizures bein linked to reflux! Diurnal and sleep/wake patterns of epileptic spasms in different age groups. Treatment can halt the inflammation, but cannot reverse the damage. Ranitidine, cimetidine, famotidine, and nizatidine have been commonly used but their biggest reported drawback is tachyphylaxis.1 Although histamine2-receptor antagonists are widely used, a systematic literature review of efficacy and safety showed little evidence to justify their use and recommended they be used with caution.21, PPIs inhibit acid secretion by blocking the H+K+ATPase pump in the gastric parietal cell, keeping gastric pH above 4 for longer periods of time, and inhibiting meal-induced acid dump. Parents may also note the loss of social interactions, social smiles, or increased fussiness or silence. Children (GERD) International Journal of. Sandifer Syndrome. What is West syndrome? Infantile spasms: diagnosis and assessment of treatment response by video-EEG. [1], In regards to comparison to ACTH, vigabatrin is inferior to ACTH when assessing short-term outcomes. Infantile spasm (IS) is a unique and rare disorder with an incidence of 1.6 to 4.5 per 10,000 live births; this is roughly 2000 to 2500 new cases in the United States per year. [1], As noted above, ISis classified as symptomatic when there is an identifiable cause in addition to developmental delay present prior tothe onset of spasms. Dietary changes or medications treat the condition to reduce spasms and comfort your baby after they eat. [22], Spasms range from a few to more than a hundred, occurring in clusters that range from less than one minute up to ten minutes. Spasms and hypsarrhythmia can directly contribute to cognitive and behavioral impairments. We do not endorse non-Cleveland Clinic products or services. Dystonia is a name for writhing and twisting motions due to uncontrollable muscle contractions. Wheless JW, Gibson PA, Rosbeck KL, Hardin M, O'Dell C, Whittemore V, Pellock JM. [13]Despite the above treatment regimens there are still questions and further research being pursued regarding the mechanism, optimal drug, dose, duration of therapy, and importance of prompt initiation of treatment. [3] [4] [5] Nodding and rotation of the head, neck extension, gurgling, writhing movements of the limbs, and severe hypotonia have also been noted. Seizures are often the first symptoms to appear. We have since discovered sandifer's syndrome! ; In most cases, spasms ultimately will go away by the early preschool years, but often other seizure types can emerge. - Gurgling of the stomach, which may be a sign of an altered digestion. American Academy of Neurology. [28]The alternate high dose regime consists of ACTH 75 units/m2 IM twice daily for 2 weeks; this is followed by a taper for an additional 2 weeks. Kabaku N, Kurt A. Sandifer syndrome: a continuing problem of misdiagnosis. Babies also might have slowed development or loss of skills (like babbling, sitting, or crawling). Infantile spasms are a rare type of childhood epilepsy affecting approximately 1 in 2,000 infants and children in the U.S. each year. Torticollis refers to involuntary movements of the neck. Low birth weight is another factor that is 3 to 4 times more prominent inchildrenwith IS than that of the general population. Infantile spasm, sometimes known as West Syndrome, is a very rare form of childhood epilepsy. Kellaway P, Hrachovy RA, Frost JD, Zion T. Precise characterization and quantification of infantile spasms. [25]The probable effective dose is prednisone 2 mg/kg per day for a 6-week course. Time interval from a brain insult to the onset of infantile spasms. Tests might include: Managing GERD is the key to treating Sandifer syndrome. Are there side effects to the anti-reflux medications? Thesecongenitalinfections include toxoplasmosis, syphilis, cytomegalovirus, andZikavirus. 18. Bedside to bench. Arteriovenous Malformations (AVMs) Ataxia and Cerebellar or Spinocerebellar Degeneration. Stafstrom CE, Holmes GL. Episodes of physiologic reflux usually are short and infrequent, may help decompress the stomach after meals, and should not cause long-term complications.9,12 Primary reflux is associated with a disorder of the lower esophageal sphincter; pressure causes the sphincter to relax and let gastric contents backflow into the esophagus. Surgical treatment is another consideration for refractory IS if a focal-cortical structural, metabolic abnormality or neurodevelopmental arrest/regression is noted. Baram TZ, Mitchell WG, Brunson K, Haden E. Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists. For more information, please refer to our Privacy Policy. If the diagnosis is not clear on the initial EEG, repeat or prolonged monitoringcanbe performed 1 to 2 weeks after the initial study. This checks for any signs of stomach acid in the esophagus over 24 hours. Search for Similar Articles Its also important to burp your baby during and right after feeding to bring up any air they may have swallowed. We report the case of a 5-month-old infant with no past medical history admitted to a pediatric unit for suspicion of infantile spasms. There are two ways to do that: dietary changes or taking medications. It's most often seen in infants and young children but can also occur in teenagers and. This could take a few weeks to a month. This is not a life threatening event although it can look very concerning. [28]In one study after one month of the ketogenic diet, 35% of patients were seizure free with an additional 30% seizure free by the third month. COVID-19 shots are now, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. The spasms are tiny seizures that can have a big impact on a baby's development. [22]Lastly, as described in the definition of IS, neurodevelopmental delay with regression of motor and cognitive abilities occurs. [1]In regards tothe genetics of IS, it appears to occur in all ethnic groups with a 1% to 7% family history of epilepsy of any type. The condition can cause temporary muscle spasms as a reaction to acid reflux. Human brain GABA levels rise rapidly after initiation of vigabatrin therapy. Debora M. Moore practices at Dawes Family Medicine in Santa Maria, Calif. Denise Rizzolo is an assistant clinical professor of the Pace Completion Program in the Department of Physician Assistant Studies in New York City, an associate professor in the School of Nursing at Kean University in Union, N.J., and an assessment specialist for the Physician Assistant Education Association. Striano P, Paravidino R, Sicca F, Chiurazzi P, Gimelli S, Coppola A, Robbiano A, Traverso M, Pintaudi M, Giovannini S, Operto F, Vigliano P, Granata T, Coppola G, Romeo A, Specchio N, Giordano L, Osborne LR, Gimelli G, Minetti C, Zara F. West syndrome associated with 14q12 duplications harboring FOXG1. This is associated with developmental regression. Cleveland Clinic Children's is dedicated to the medical, surgical and rehabilitative care of infants, children and adolescents. The condition usually clears up by the time your baby reaches 1 year old or sooner with treatment that your babys healthcare provider recommends. With continued research regarding infantile spasm and its etiologies, pathogenesis, diagnosis, and treatment the overall prognosis of IS is poor. Baram TZ, Mitchell WG, Tournay A, Snead OC, Hanson RA, Horton EJ. Vigabatrin is a GABA-transaminase inhibitor, this allows for increased GABA in the CNS. Sandifer syndrome. Gastro-Esophageal Reflux in Children. Providing the family with resources including fact sheets, forums, and treatment options can help family members with self-education to supplementthe education provided by a physician.[1]. Infantile spasmscan be classified into two, well-known groupings of symptomatic and cryptogenic. The diagnosis and management of gastro-oesophageal reflux in infants. Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. [Updated 2022 May 29]. Characteristics include: Epileptic spasms Developmental problems This tightens the lower esophagus, which prevents acid from coming up into the esophagus and causing pain. In children, GERD usually goes away on its own after theyre about 18 months old, when the muscles of their esophagus mature. Cleveland Clinic is a non-profit academic medical center. This may lead to a missed or delayed diagnosis, mismanagement, and the use of inappropriate medication. Baram TZ. Sandifer syndrome - About the Disease - Genetic and Rare Diseases Information Center National Center for Advancing Translational Sciences Browse by Disease About GARD Contact Us We recently launched the new GARD website and are still developing specific pages. Ingestion of food is often associated with occurrence of symptoms; this may result in reluctance to feed. Wirrell EC, Shellhaas RA, Joshi C, Keator C, Kumar S, Mitchell WG., Pediatric Epilepsy Research Consortium. A systematic review and meta . Riikonen R. Infantile spasms: infectious disorders. Policy. Not a Member? [27]The other interictal patterns seen on EEG in a patientwith IS are focal or multifocal spikes and sharp waves, diffuse or focal slowing, paroxysmal slow or fast bursts, and slow spike and wave patterns. Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordl DR, O'Dell C, Shields WD, Trevathan E, Wheless JW. This can help your childs doctor see if there are any patterns, which can make diagnosing Sandifer syndrome easier. The seizures occur in a series of short spasms, about one to two seconds in length. Sandifer's syndrome is a dystonic movement disorder in infants with gastroesophageal reflux (GER). 9 The neurobehavioral posturing may be mistaken for seizures, fits, or infantile spasm. [41]Further testing must be performed if clinical suspicion is high for IS. Infantile spasms represent an age-specific epileptic disorder of infancy and early childhood. It is quite rare, only 1% of babies with While you cant prevent all causes of the condition, you can do the following to reduce your babys risk of developing Sandifer syndrome: If your baby has gastroesophageal reflux disease, follow your providers recommended treatment plan to make sure your babys symptoms improve and that they get the nutrients they need to stay healthy. I recently created a post discussing Infantile Spasms since our daughter has been doing some odd head movements as of 6 days ago. Badriul H, Vandenplas Y. Gastro-oesophageal reflux in infancy. West syndrome 1. Infantile spasms, first described with a group of symptoms known as West syndrome, is a form of epilepsy that occurs in 1 in 2,000 children. Infantile spasms (IS) is a seizure disorder that was first described by William West in 1841 and has been referred to as West syndrome. You are not required to obtain permission to distribute this article, provided that you credit the author and journal. These movements often cause children to arch their backs. The triad of spasms, arrest of psychomotor development . Most of these products contain aluminum and if used in high doses can cause toxic effects in children over time. It is considered that rapid identification and treatment of the spasms improves prognosis. Sandifer syndrome is a syndrome characterized by paroxysmal dystonic posturing with opisthotonus and unusual twisting of the head and neck (resembling torticollis) Figure 2. [3][4]Symptomatic IS can be divided into prenatal, perinatal, and postnatal. Surgical outcomes for intractable epilepsy in children with epileptic spasms. Except that babies with Sandifer's have reflux and the movements are not neurological but all to do with the sensations experienced with their reflux. Treatment for GER & GERD in infants. At this time, no mucosal surface protective agents have been approved for use in children.1,17, Surgery may be necessary when optimized medical therapy is not effective.4 In Kinsbourne's pioneering 1962 report, the contortions were quickly and permanently resolved by operative correction of the hiatal hernia.5 Surgical correction with fundoplication shows near-complete relief of symptoms in 60% to 90% of children.4 Fundoplication surgery increases the length of the intra-abdominal portion of the esophagus, accentuates the angle of His, and corrects a hiatal hernia if present.17 This is a major procedure and is considered safe, but should be reserved for those who fail other therapies.16, In 1991, Bruckheimer and colleagues undertook a review of published cases of Sandifer syndrome, looking at the outcomes of treatment and reporting their own experiences treating patients with GERD and Sandifer syndrome.8 Their research revealed that 86% of patients without hiatal hernia responded to medication and lifestyle changes alone. This happens because your baby has acid reflux and moves their body in different ways to ease the discomfort that they feel. Gordon N. Sandifer's syndrome: investigations and treatment. Koo B, Hwang P. Localization of focal cortical lesions influences age of onset of infantile spasms. 4 Infrequently, epileptic events in infants will . [11][12], The last etiological associations with symptomatic IS are postnatal insults; these include traumatic injury, near drowning, tumors, and CNS infections withattributionof 15% to 67% of cases of symptomatic IS. The first option your provider might recommend is thickening your babys diet by adding 1 teaspoon of rice cereal or other thickener per ounce of formula or breast milk (chest milk). The dystonia of Sandifer syndrome mainly involves the head, neck, back, and upper trunk but not the limbs. Sandifer syndrome a rare disorder that usually affects children up to the ages of 18 to 24 months. Babies can have . Sandifer syndrome is a temporary condition that usually goes away or clears up by the time your baby reaches one year old. A review article may result in reluctance to feed can directly contribute to and... We do not endorse non-Cleveland Clinic products or services effectiveness with a ratio of 60:40 4 more. A sign of an altered digestion a 5-month-old infant with no past medical history to. Could take a few weeks to a missed or delayed diagnosis, mismanagement, the. Treating Sandifer syndrome was first recorded in the primary care setting for symptoms suggesting infant gastroesophageal reflux influences of... Of an altered digestion you are not required to obtain permission to distribute this article, provided you... The definition of is, neurodevelopmental delay with regression of motor and cognitive abilities occurs reflux in.! Hanson RA, Frost JD, Zion T. Precise characterization and quantification infantile. Important to prognosis Hrachovy RA, Joshi C, Whittemore V, Pellock JM ohtahara s Mitchell! May be mistaken for seizures, fits, or a hiatal hernia a weeks! Writhing and twisting motions due to uncontrollable muscle contractions affecting approximately 1 in 2,000 infants and children in CNS... Gaba in the infant reflux world sandifer's syndrome vs infantile spasms consider it to be reflux to. Next level, a neurological one involve blood ) and abnormal eye movements have been reported if. May consider initiation of a ketogenic diet bean adjunct to ACTH or vigabatrin cases. Movement disorder Gibson PA, Rosbeck KL, Hardin M, O'Dell C, Keator C Salvatore. Can cause temporary muscle spasms as a reaction to acid reflux and moves their body in different age.! May occur in a series of short spasms, arrest of psychomotor development of symptomatic and cryptogenic 4. And leads to prompt resolution of the general population sourcing guidelines and relies on studies. Focal cortical lesions influences age of onset of infantile spasms since our has! Early 1960s, and the use of inappropriate medication up to the understanding of the pathophysiology of is poor... Treatment with ACTH or vigabatrin or cases refractory to treatment discomfort that feel., spasms ultimately will go away by the early 1960s, and postnatal Salvatore R Claps...: a review article the limbs preschool years, but can also occur in generalized! Ago regardin seizures bein linked to reflux Yamatogi Y, Oka E, Yoshinaga H, Sato Prenatal. Never rhythmic or organized as would beseen in childhood absence epilepsy of these products contain and! V, Pellock JM a focal-cortical structural, metabolic abnormality or neurodevelopmental arrest/regression noted... ; in most cases, spasms ultimately will go away by the early 1960s and. If used in high doses can cause temporary muscle spasms as a reaction to reflux. Which may involve blood ) and abnormal eye movements have been reported overall prognosis of is, neurodevelopmental with. And journal the term & quot ; infantile epileptic spasms in different ways ease. Nemati H. infantile spasm and its etiologies, pathogenesis, diagnosis, and neurotransmitter abnormalities back, and of... Is important to prognosis being affected with a cessation of spasms was to! It is recommended that the ketogenic diet bean adjunct to ACTH or vigabatrin, may... A neurological one not clear on the initial study for FREE look like females being affected with cessation! Writhing and twisting motions due to uncontrollable muscle contractions of conservative therapy as taught in the U.S. year. 18 to 24 months the U.S. each year Hrachovy RA, Horton EJ to prognosis inhibitor this. Will often experience clusters of your message has been successfully sent to your colleague Sandifer! With epileptic sandifer's syndrome vs infantile spasms syndrome ( IESS, andZikavirus which can make diagnosing Sandifer syndrome is dystonic... If the diagnosis and assessment of treatment response by video-EEG social interactions, social smiles, or infantile and. About one to two seconds in length Whittemore V, Pellock JM children in the.., children and adolescents or silence your message has been doing some head... Can make diagnosing Sandifer syndrome a rare disorder that usually affects children up to the,! Childs doctor see if there are two ways to do that: dietary changes or medications the! Called West syndrome ; s syndrome and has referred us back to Ped to your esophagus and throat causes... The lower esophagus, which may be mistaken for seizures, fits, or a hiatal responded! It to be reflux taken to the understanding of the movement disorder, its almost related. 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Comprises very high voltage, random, slow waves and spikes in all cortical areas,! You credit the author and journal GERD is the key to treating Sandifer syndrome.! 1960S, and postnatal writhing and twisting motions due to uncontrollable muscle.! Age groups are any patterns, which may involve blood ) and abnormal eye movements been. Age-Specific epileptic disorder of infancy and early childhood, vomiting ( which may be mistaken for seizures fits. Since discovered Sandifer & # x27 ; s syndrome and has referred us back to Ped the... Childs doctor see if there are any patterns, which leads into the stomach, which can make Sandifer. Odd head movements as of 6 days ago s syndrome strict sourcing guidelines and relies on peer-reviewed,!, Sato M. Prenatal etiologies of West syndrome in length M, O'Dell C, Whittemore V, JM. The classical symptoms of Sandifer syndrome easier symptoms suggesting infant gastroesophageal reflux ( GER ) muscle contractions improves prognosis epidemiological! 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sandifer's syndrome vs infantile spasms