2022 Oct 21;13:475. doi: 10.25259/SNI_377_2022. in The text in one post reads: BOMBSHELL: Biological Study PROVES Pfizer mRNA Vaccine Permanently Alters Human DNA. 2020 Apr 9;3:100051. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? For general inquiries, please use our contact form. And, this month, we saw a few of the many ways that science can be misinterpreted and misused. Fax: +46 (0)46 222 47 20, Invoice address: Box 188, 221 00 Lund But the study did not demonstrate that anything further happened with the converted DNA. Since Hypothesis and Theory articles in this journal do not require methods or results sections, this paper met the criteria for publication. FOIA Turn on javascript for best performance. Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines. BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. BNT: BNT162b2; L: DNA ladder; Ctrl1: cultured Huh7 cells; Ctrl2: Huh7 cells without BNT162b2 treatment collected at 6 h; Ctrl3: Huh7 cells without BNT162b2 treatment collected at 24 h; Ctrl4: Huh7 cells without BNT162b2 treatment collected at 48 h; Ctrl5: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h; Ctrl6: RNA from Huh7 cells treated with 0.5 g/mL of BNT162b2 for 6 h, digested with RNase. 2022 Nov;28(11):2273-2287. doi: 10.1038/s41591-022-02061-1. Case presentation: We report a case of hepatic artery occlusion after the first dose vaccination by ChAdOx1nCov-19. Dr. Peter McCullough, an internist, cardiologist, and epidemiologist,wrote on Twitterthat the Swedish studys findings have enormous implications of permanent chromosomal change and long-term constitutive spike synthesis driving the pathogenesis of a whole new genre of chronic disease.. Anti-vaccination and ivermectin proponents have gone bananas over the new study from the Lund University YDM: The attention of the media and the general public reflects a concern among some regarding new vaccine technologies. 8600 Rockville Pike BNT162b2 mRNA is reverse transcribed intracellularly into DNA as fast as 6 [hours] after BNT162b2 exposure.. We show that the vaccine enters liver cells as Different vaccine platforms including the full-length spike mRNA (Pfizer-BioNTech and Moderna vaccines), spike adenovirus-based DNA (AstraZeneca and Johnson & Johnson), and spike protein (Novavax) were developed to induce a specific neutralizing response against SARS-CoV-2. Studies comparing the amount of live virus shed during infection with the amount of RNA detected by PCR have not shown the two measures to be well correlated. MR: These findings were observed in petri dishes under experimental conditions, but we do not yet know if the converted DNA is integrated into the cells' DNA in the genomeand if so, if it has any consequences. An official website of the United States government. Two of the authors, Associate Professor Yang de Marinis (YDM) and Professor Magnus Rasmussen (MR), share their views. Careers. Its the first time that researchers have shown in vitro or inside a petri dish how an mRNA vaccine is converted into DNA on a human liver cell line, the Epoch Times reported. A segment of the protein called the open reading frame-1, or ORF-1, then goes back into the nucleus, where it attaches to the vaccines mRNA and reverse transcribes into spike DNA. Privacy policy In this study, we investigated the effect of BNT162b2 on the human liver cell line Huh7 in vitro. 1 . Whether our results are true for other cell types in humans, or if they are specific to mRNA vaccines, are among many questions for further research. This genetic material contains instructions the body's cells use to build a protein found in a bacterium or virus, and that protein is then recognized by the immune system. As such, by definition, a modeling study cannot serve as proof. Reuters has previously fact checked the claim that mRNA vaccines alter human DNA (here), (here), (here) and (here). So even if people were equally contagious in the first few days of infection, vaccinated people generally would have been contagious for a shorter period of time. The authors of a Swedish study said their study could not be used to draw conclusions with human DNA as they used cell lines in a laboratory petri dish for their work. Clin Microbiol Infect. YDM: More research is needed. It did not assess whether the vaccine alters the human genome, or what the effects of that would be, according to experts and the study authors. According to Swedish researchers at Lund University, the messenger mRNA from Pfizers Covid vaccine can enter human liver cells and is converted into DNA. Please enable it to take advantage of the complete set of features! On the figure, the two lines (comparing vaccinated and unvaccinated patient data) are almost in the same place for the first four or five days of illness, but then they separate, and the vaccinated group more quickly requires higher numbers of PCR cycles to detect viral RNA, meaning there was less virus in those samples. However, we do not guarantee individual replies due to the high volume of messages. An important thing to notice when looking at this figure is that unlike most axis numbers, those on the y-axis showing cycle threshold are decreasing in number as they go higher on the graph. Shakira. All versions of Internet Explorer are no longer supported, either by us or Microsoft (read more here: (Infographic). WebPrevious vaccines were largely attenuated or live vaccines that were bioengineered to not cause as severe of a reaction while still being similar enough to the origin virus to cause us to gain immunity. Furthermore, a recent study showed that SARS-CoV-2 RNA can be reverse-transcribed and integrated into the genome of human cells. Illustration, BNT162b2 mRNA levels in Huh7 cells treated with BNT162b2. Accessibility statement. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage Further, the newest vaccines are personalized, meaning they can target a patients Intracellular reverse transcription of Pfizer BioNTech COVID-19 mRNA vaccine BNT162b2 in vitro in human liver. Indeed, about 8 percent of human DNA comes from viruses inserted into our genomes during evolution. Safety and Efficacy of the BNT162b2 mRNA COVID-19 Vaccine. YDM: One of the limitations of our study is that we dont know if what we observed in this cell line could also happen in cells of other tissue types, and this needs to be addressed in follow-up studies. And this could be seen with natural virus infection as well, Moore said. Additionally, the mRNA vaccine does in fact travel to the liver and other locations such as ovaries. The blood samples were analyzed for the virus that causes COVID-19 by subjecting them to polymerase chain reaction (PCR) testing. Salesforce has already slashed 8,000 workers from its ranks this year. 2023 Jan 19. The more virus in a sample, the fewer cycles it would take to detect RNA. Bad Bunny. A Clinical Update on SARS-CoV-2: Pathology and Development of Potential Inhibitors. Its precisely what health experts and fact-checkers said for more than a year could not occur. The American Association of Liver Disease has recently published consensus statements for COVID-19 vaccination in subjects with chronic liver disease (CLD). eCollection 2022 Dec. Mavridis C, Aidonidis G, Evangelou M, Kalogeridis A. Hist Philos Life Sci. Materials in this section are updated as new information and vaccines become available. Kids will surely love it Serve with crusty bread! In the case of Covid shots, the vaccines from Moderna and Pfizer /BioNTech introduce a single spike protein. 5. This will lead to some parts of our website to not work properly or at all. Thank you for taking time to provide your feedback to the editors. While that point alone is enough to confirm that this paper does not offer evidence that COVID-19 vaccines cause ADE, it is also worth noting that the Methods section of the paper contains only five sentences, and the author describes looking at online protein banks and comparing the SARS-CoV-2 spike protein sequence to sequences of other proteins. Nature. Knowing that it is theoretically possible for RNA from a virus or RNA from a vaccine to be incorporated into a cell line in a test tube is very, very different from knowing whether that cell would then survive the bodys immune system and if it did survive the bodys immune system, would make any difference, Strain said. You can unsubscribe at any time and we'll never share your details to third parties. Unable to load your collection due to an error, Unable to load your delegates due to an error. Both boys were pronounced dead at home. Dr. Peter McCullough, an internist, cardiologist and epidemiologist who is one of the leading critics of the COVID vaccines, said the findings have enormous implications of permanent chromosomal change that could drive a whole new genre of chronic disease., The CDC assures Americans that the mRNA and the spike protein it produces in COVID-19 vaccines to create an immune response dont last long in the body. On its website, the agency states: Our cells break down mRNA and get rid of it within a few days after vaccination. We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. One, theyre RNA or mRNA vaccines, and two, they seem to be very effective, at least in the limited clinical trials theyve done. Suggested accounts. The results have been widely discussed across social mediabut the results have in many cases been misinterpreted. Missing context. We saw that there was DNA converted from the vaccine's mRNA in the host cells we studied. The results have been widely discussed across social media but the results have in many cases been misinterpreted. YDM: More research is needed. Would you like email updates of new search results? More information: Mandatory vaccinations, the segregation of citizens, and the promotion of inequality in the modern democracy of Greece and other democratic countries in the era of COVID-19. Likewise, proteins from pathogens are sometimes going to share similar stretches with our proteins as well. See this image and copyright information in PMC. Antibody levels were also measured in separate tests. 2022 Dec 7;44(4):72. doi: 10.1007/s40656-022-00548-1. Neither your address nor the recipient's address will be used for any other purpose. DNA, contained in all cells, is the building block of the bodys genetic code. Reverse transcription is when DNA is made from RNA, whereas the normal transcription process involves a portion of the DNA serving as a template to make an mRNA molecule inside the nucleus. The authors likely opted to show the data this way because a lower cycle threshold means a sample had more virus, so when they plot the data, those higher on the graph represent samples with more virus compared with those lower on the graph. Comment on Aldn et al. Differences in mRNA-1273 (Moderna) and BNT162b2 (Pfizer-BioNTech) SARS-CoV-2 vaccine immunogenicity among patients undergoing dialysis. Spetzofai is a rustic spicy Greek dish that is made with thick sausages and long green and red peppers in a rich tomato sauce. (In-vitro Swedish Study)" by Drbeen Medical Lectures This three-part series was aimed at describing several important aspects of science. Data, especially data from vaccinated humans, will hopefully sort out the question marks. Click here:\rhttps://www.drbeen.com/yt-special-p/\r\rWant to support this work? Front Immunol. Magnus Rasmussen Selena Gomez. Does the Pfizer-BioNTech mRNA vaccine get converted to DNA or not? And yet, it has become commonplace for anti-vaccine activists to refer to the mRNA vaccines as gene therapy. Every cell within our human body is undergoing regular checks, and when you get an abnormal cell, that abnormal cell is then broken down and deleted, Strain said. In the August 2022 James Gill paper titled Autopsy Histopathologic Cardiac Findings in 2 adolescents following the second COVID-19 vaccine dose, two teenage boys died in their sleep within the first week after receiving the 2nd Pfizer COVID-19 mRNA vaccine dose. The study authors, in March after it received significant attention, stating this study does not investigate whether the Pfizer vaccine alters our genome, and that there is no reason for anyone to change their decision to take the vaccine based on this study.. eCollection 2022. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). But keep in mind, when the mRNA or adenovirus particles do hit cells outside of the liver or the site of injection, they're still causing them to express Spike protein anchored on their surfaces, not dumping it into the circulation. 41.1M. It is the three-dimensional (3D) structure. Our Standards: The Thomson Reuters Trust Principles. It is a good tool when studying molecular and cellular processes, they are easy to research, and since the cell lines are easily accessible, studies often start with various cell lines. YDM: This study does not investigate whether the Pfizer vaccine alters our genome. ADE is a condition in which the antibodies against a pathogen increase the ability of the pathogen to get into cells. , ! followers 26 videos. Immunohistochemistry using antibody binding to LINE-1 open reading frame-1 RNA-binding protein (ORFp1) on Huh7 cells treated with BNT162b2 indicated increased nucleus distribution of LINE-1. 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One post reads: BOMBSHELL: Biological study PROVES Pfizer mRNA vaccine get converted to DNA or?.
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